4.5 Ketogenic Diet


What happens if you eat a very low-carb, high fat diet ?

One study finds higher levels of Akkermansia and Parabacteroides reduce production of gamma-glutamylation and modulate hippocampal GABA/glutamate ratios.124

Here is the microbiome of a person who tried Keto for several weeks.

Now let’s compare two people. The red line is the person above, who tracked their microbiome while beginning the diet; the blue line is a person who has been on a ketogenic diet for six months or so. Interestingly, the genus Parasutterella seems in unusually high abundance in both cases. Does it somehow relate to a low carb diet?


Olson, Christine A., Helen E. Vuong, Jessica M. Yano, Qingxing Y. Liang, David J. Nusbaum, and Elaine Y. Hsiao. 2018. “The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet.” Cell 173 (7): 1728–1741.e13. https://doi.org/10.1016/j.cell.2018.04.027.